Two components of coffee protects from Parkinson’s disease

Two components of coffee protects from Parkinson’s disease

04/12/2018

Specialists Medical school Robert wood Johnson (USA) found new evidence that drinking coffee reduces the risk of developing neurodegenerative diseases. In particular, the researchers found that two components of coffee, caffeine and eicosanol-5-hydroxytryptamin act as a cure for Parkinson’s disease, protecting brain neurons from damage. The results of this study were published the journal PNAS.

Researchers conducted a series of experiments with genetically modified mice with Parkinson’s disease. It is a severe neurodegenerative disease develops in connection with the death of dopamine-mediated error of neurons due to the accumulation of protein alpha-synuclein (Lewy body). Concentrations of protein, in turn, are due to reduced activity of the enzyme phosphatase PP2A.

Experiments with mice showed that the two components of coffee, caffeine and eicosanol-5-hydroxytryptamin, can act as a cure – together, they protect the brain against destructive accumulation of alpha-synuclein. Mice that born meat was added to subtherapeutic doses of these components, six months later, showed the best result in passing of behavioural tests than mice from the control group who did not receive the coffee supplements in the food. In rodents, in which were two component of the aforementioned coffee, in the brain were observed accumulations of the protein alpha-synuclein, giving impetus to the development of Parkinson’s disease. While individually the ingredients of coffee’s protective effect was not shown.

Scientists believe that these two components of the coffee act through different mechanisms on the same target enzyme, not allowing it to accumulate protein alpha synuclein in the brain. Also, researchers believe that they observed are substances coffee is not the only, giving the effect of brain protection in a pair

“Coffee can contain about a thousand active ingredients that are able to show a complementary effect,” said the authors.
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