Vaping may leave lungs with ‘chemical burns’ biopsies find

Vaping may leave lungs with ‘chemical burns’ biopsies find


Vaping can leave lungs with ‘chemical burns seen in industrial accidents,’ study reveals, as US death toll hits 17

  • Over 800 people in the US have lung illnesses from vaping and 17 have now died
  • On Tuesday, Alabama reported its first vaping-related death
  • Mayo Clinic scientists performed biopsies on the lung tissue of 17 vaping illness patients, two of whom died 
  • 71% of the those patients used marijuana products 
  • Across the board, the scientists found the damage was most like ‘chemical burns’ from toxic fumes  

The hundreds of vaping illnesses and over a dozen deaths are likely caused by toxic fumes from e-cigarettes, a first-of-its kind study suggests. 

More than 800 Americans have suffered severe lung damage and, as of Wednesday, an additional death was reported in Alabama, bringing the national total to 17 vaping-related fatalities. 

As illnesses and deaths have mounted, scientists have been scrambling for answers and have cautiously proposed a number of theories. 

At last, Mayo Clinic researchers can offer a clearer explanation: it’s not lipid pneumonia, as some have suggested, but ‘direct damage’ akin to what happens to lungs exposed to chemical fumes. 

With the addition of one death in Alabama, vaping-related illnesses have now killed 17 Americans in 15 states. Mayo Clinic experts reported 17 lung tissue samples have the sort of damage they would expect to see in victims of industrial chemical spills 

They are the first to look at fine details of damaged lungs through biopsies of tissue samples from 17 vaping patients – most of whom had used cannabis oils. 

‘I don’t think anything can be ruled out in terms of potential culprits or things that are not causing [these injuries],’ lead study author Dr Brandon Larsen told 

‘But the kind of pattern we’re seeing most closely resembles the kind of toxic inhalation we would see from somebody who has been involved in a big industrial accident with a chemical spill and toxic fumes that are inhaled and produce something like a chemical burn to the lung tissues and airways.’ 

Many of the early studies and case reports on the vaping illnesses suggested that the illnesses were likely related to oils in the vape liquids. 

They said that the patients’ conditions looked like lipid pneumonia, a rare lung illness in which fat particles accumulate in the lungs and trigger inflammation. 

Some of these were based on images taken of patient lungs.

But even those don’t look like what doctors would expect to see in lipid pneumonia, according to Dr Larsen, a whose pathology lab is trusted by doctors the world over to parse out the causes of the hardest-to-solve cases of respiratory illnesses. 

‘We became interested because of this information stating that the illnesses may be due to accumulation [of lipids] in the lungs, but there’s been some misunderstanding and misinformation about what this process really is in the lungs,’ he said. 

‘Everything we thought we knew about this is probably based on indirect findings.’  

Instead, he and his team went straight to the source, performing biopsies on 17 samples of lung tissue from patients suffering vaping-related illnesses, including two that died. 

All of the patients had reported vaping, and 71 percent said they had vaped some form of marijuana or cannabis oils, although some reported using THC, and others used CBD. 

Across board, they found the same kind of toxic fume-like damage, according to the new study, published in the New England Journal of Medicine. 

So, ‘maybe we have incomplete information, or maybe there’s some other explanation, some other contaminants,’ that have not yet been identified, said Dr Larsen. 

He noted that patients may not be willing to disclose that they’ve vaped potentially illegal marijuana products, many are unable to speak by the time they’re admitted to hospitals, and their families may have no awareness of what they are using. 

So for now, nothing can really be ruled out. 

‘We believe that the best explanation is that there’s some kind of toxicant injury from fumes of whatever substance or substances it happens to be,’ said Dr Larsen. 

‘It’s probable that it could be a number of different things – toxic chemical contaminants, from the Chinese lab, from people the get them from online on the black market. 

‘That’s what it appears to be, to us.’ 

Mayo Clinic is working closely with the Centers for Disease Control and Prevention to try to develop a set of clearer diagnostic criteria and guidance. 

At least for now, vaping-related illness has to be diagnosed by exclusion – by ruling out everything it’s not in order to determine what it must be. 

And, although the Mayo Clinic pathology study helps to shed light on how exactly vaping is damaging people’s lungs, it doesn’t tell us much more about how to treat or save them. 

‘At the moment, it would not change what [clinicians] are doing,’ says Dr Larsen. 

‘There’s nothing we can do for chemical injuries beyond supportive care, so we can give supportive oxygen, a breathing tube, and many patients will respond to steroids, but we’re still learning what could be done to help patients with this problem.’   

Source: Read Full Article